2018 Mar 14;17(1):39. doi: 10.1186/s12933-018-0682-3. For a clinician who works to achieve optimal outcomes, glucose-lowering therapies form part of a multifactorial intervention package. Currently, 4 large cardiovascular outcome trials have established the cardiovascular safety of DPP-4 inhibitors vs placebo in patients with type 2 diabetes at a high cardiovascular risk, 20-23 including the Cardiovascular and Renal Microvascular Outcome Study with Linagliptin (CARMELINA). Good yields have been achieved following cereal crops on fields which would otherwise have been fallow. The top-line results of the CAROLINA trial indicate that linagliptin is non-inferior to glimepiride. Linagliptin (CARMELINA) was designed to evaluate the CV safety and kidney outcomes of linagliptin in patients with type 2 diabetes at high cardiorenal risk. Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA(®)): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk. The CARMELINA trial was a long-term clinical study of the dipeptidyl peptidase 4 (DPP4) inhibitor linagliptin in patients with type 2 diabetes that conï¬rmed the noninferiority of linagliptin plus standard of care (SoC) versus SoC for 3-point major adverse cardiovascular events. with LINAgliptin (CARMELINA®):andomized, double-blind,ebo -controlled clinical trial in patients with t2es and high cardio-renal risk Julio Rosenstock1*,Vlado Perkovic 2,John H. Alexander3,Mark E. Cooper4,Nikolaus Marx5,Michael J. Pencina3, Camelina grows rapidly and, in Montana field trials, completed its lifecycle a few weeks sooner than spring wheat. Prior trials have demonstrated CV safety of 3 dipeptidyl peptidase 4 (DPP-4) inhibitors but have included limited numbers of patients with high CV risk and chronic kidney disease. Importance Type 2 diabetes is associated with increased cardiovascular (CV) risk. Randomized, double-blind, placebo-controlled, multicenter noninferiority trial conducted at 605 clinic sites in 27 countries, enrolling adults with type 2 diabetes and HbA 1c 6.5-10.0%. Participants in CANVAS were randomly assigned in a 1:1:1 ratio to receive cana - â¦ The ongoing CARMELINA trial is examining the CV and renal safety of linagliptin in diabetic patients with high CV risk as compared to placebo. Design, setting, and participants: Randomized, double-blind, active-controlled, noninferiority trial, with participant screening from November 2010 to December 2012, conducted at 607 hospital and primary care sites in 43 countries involving 6042 participants. In a similar group of patients, the ongoing CAROLINA study is assessing the CV safety of linaglitin compared to â¦ CARMELINA (The Cardiovascular and Renal Microvascular Outcome Study With Linagliptin) was designed to evaluate the cardiovascular safety and kidney outcomes of linagliptin, a highly selective DPP-4 inhibitor with minimal renal excretion, 15 in people with T2DM at high cardiovascular and renal risk. Cardiovasc Diabetol. 646 n engl j med 377;7 nejm.orgAugust 17, 2017 The new england journal of medicine by the trial sponsor.
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